Rhenium-labeled somatostatin analog RC-160. 1H NMR and computer modeling conformational analysis.
نویسندگان
چکیده
منابع مشابه
1H-NMR stereospecific assignments by conformational data-base searches.
A search procedure is described for making stereospecific assignments at prochiral centers in proteins on the basis of nuclear Overhauser enhancement and coupling constant data derived from nmr experiments. A data base comprising torsion angles, associated 1H-1H coupling constants and interproton distances is searched by a computer algorithm for sets of values that match the experimental data w...
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In this paper the attention is drawn on analog computer.For scientists attempting to prepare complex designs for simulation approach the analog computer assisted them. Extensive knowledge about the analog methods is required before preparing any analog design. The credit for the advent of analog computer goes to the invention of operational amplifier. Thus in 1950 the engineers and aircraft res...
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Female Syrian golden hamsters with /V-nitrosobis(2-oxopropyl)amineinduced pancreatic cancers were treated for 2 months with new pseudononapeptide bombesin receptor antagonist |D-Tpi6,Leu'V(CH2NH)Leul4)bombesin(6-14XRC-3095), administered s.c. with implanted os motic minipumps releasing 20 «ig/dayof the analogue. The results were compared to those obtained by treatment with somatostatin analogu...
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Female Syrian golden hamsters with N-nitrosobis(2-oxopropyl)amine-induced pancreatic cancers were treated for 2 months with new pseudononapeptide bombesin receptor antagonist [D-Tpi6,Leu13 psi (CH2NH)-Leu14]bombesin(6-14)(RC-3095), administered s.c. with implanted osmotic minipumps releasing 20 micrograms/day of the analogue. The results were compared to those obtained by treatment with somatos...
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A modified method for the preparation of a radiolabeled analog of somatostatin (123I-octreotide) is described. The pharmacokinetics and dosimetry of this analog were evaluated in patients with neuroendocrine tumors. Thirty patients had multiple blood and urine samples and sequential anterior and posterior whole-body scintigraphy up to 40 hr postinjection of 123I-octreotide. Region of interest a...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1994
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)99915-1